Tienylazolylalkoxyethanamines, their preparation and application as medicaments

• Main Authors: ANDALUZ-MATARO BLAS, FRIGOLA-CONSTANSA JORDI, MERCE-VIDAL RAMON
• Format: Patent
• Language: Czech; English
• Published: 25.07.2007
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Thienylazolylalkoxyethanaminy vzorce I, ve kterémje skupina R1 atom vodíku, atom halogenu nebo nizsí alkylová skupina; R2, R3 a R4 jsou nezávisle atom vodíku nebo nizsí alkylová skupina; a Az je dusíkatý N-methylsubstituovaný heterocyklický aromatický peticlenný kruh, který obsahuje 1 az 3 atomy dusíku. Tyto látky mají u savcu vcetne cloveka analgetickou aktivitu. Slouceniny vzorce I lze získat napríklad reakcí hydroxythienylazolu IV s vhodným derivátem N-ethylaminu. Slouceniny IV jsou vhodné meziprodukty syntézy sloucenin I. Slouceniny I jsou vyuzitelné v lidské a veterinární medicíne. Resení se téz týká farmaceutického prostredku obsahujícího slouceninu vzorce I. In the present invention, there are disclosed thienylazolylalkoxyethanamines of the general formula I in which R1 represents a hydrogen atom, a halogen atom or a lower alkyl group; R2, R3 and R4 represent, independently on each other, a hydrogen atom or a lower alkyl group; and Az represents a five-membered N-methyl-substituted nitrogenous heterocyclic aromatic ring containing from one to three nitrogen atoms. These compounds exhibit analgesic activity in mammals, including humans. The compounds of the general formula I can be obtained, for example, by reacting hydroxy-thienyl azole IV with a derivative of a suitable N-ethylamine. The compounds of the general formula IV are useful intermediates in the synthesis of the compounds of the general formula I. The compounds of the general formula I have an application in human and/or veterinary medicine. The invention also relates to a pharmaceutical composition in which the compound of the general formula I is comprised.