Oligonucleotide analogs, process of their preparation and use
Analogy oligonukleotid obecn ho vzorce I a zp soby jejich v²roby a jejich pou it jako inhibitor exprese gen (antisense-oligonukleotid , ribozym , sense-oligonukleotid a oligonukleotid tvo° c ch triplexy), jako sond pro d kazy nukleov²ch kyselin a jako pomocn²ch l tek v molekul rn biologii. Popisuje...
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Main Authors | , , , |
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Format | Patent |
Language | Czech English |
Published |
16.07.2003
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Edition | 7 |
Subjects | |
Online Access | Get full text |
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Abstract | Analogy oligonukleotid obecn ho vzorce I a zp soby jejich v²roby a jejich pou it jako inhibitor exprese gen (antisense-oligonukleotid , ribozym , sense-oligonukleotid a oligonukleotid tvo° c ch triplexy), jako sond pro d kazy nukleov²ch kyselin a jako pomocn²ch l tek v molekul rn biologii. Popisuje se rovn pou it t chto slou enin pro l en onemocn n , kter jsou zp sobovan viry, kter jsou ovlivn na integriny nebo adhezn mi receptory bu ka-bu ka, nebo kter jsou zp sobena faktory jako je TNF-alfa, nebo pro l en rakoviny nebo resten zy.\
The present invention relates to oligonucleotide analogs of the general formula I, processes of their preparation as well as their use as gene expression inhibitors (antisense oligonucleotides, ribozymes, sense oligonucleotides and triplex-forming oligonucleotides), as probes for the detection of nucleic acids and as auxiliaries in molecular biology. there is also described the use of these compounds for treating virus-induced diseases and being influenced by integrins or adhesive receptors of cell-cell type or that are caused by factors such as TNF-alpha factor or for treating cancer or restenosis. |
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AbstractList | Analogy oligonukleotid obecn ho vzorce I a zp soby jejich v²roby a jejich pou it jako inhibitor exprese gen (antisense-oligonukleotid , ribozym , sense-oligonukleotid a oligonukleotid tvo° c ch triplexy), jako sond pro d kazy nukleov²ch kyselin a jako pomocn²ch l tek v molekul rn biologii. Popisuje se rovn pou it t chto slou enin pro l en onemocn n , kter jsou zp sobovan viry, kter jsou ovlivn na integriny nebo adhezn mi receptory bu ka-bu ka, nebo kter jsou zp sobena faktory jako je TNF-alfa, nebo pro l en rakoviny nebo resten zy.\
The present invention relates to oligonucleotide analogs of the general formula I, processes of their preparation as well as their use as gene expression inhibitors (antisense oligonucleotides, ribozymes, sense oligonucleotides and triplex-forming oligonucleotides), as probes for the detection of nucleic acids and as auxiliaries in molecular biology. there is also described the use of these compounds for treating virus-induced diseases and being influenced by integrins or adhesive receptors of cell-cell type or that are caused by factors such as TNF-alpha factor or for treating cancer or restenosis. |
Author | WALLMEIER HOLGER DR UHLMANN EUGEN DR PEYMAN ANUSCHIRWAN DR BREIPOHL GERHARD DR |
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Title | Oligonucleotide analogs, process of their preparation and use |
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