Oligonucleotide analogs, process of their preparation and use

• Main Authors: WALLMEIER HOLGER DR, UHLMANN EUGEN DR, BREIPOHL GERHARD DR, PEYMAN ANUSCHIRWAN DR
• Format: Patent
• Language: Czech; English
• Published: 16.07.2003
• Edition: 7
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; AGRICULTURE; ANIMAL HUSBANDRY; BEER; BIOCHEMISTRY; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; DERIVATIVES THEREOF; ENZYMOLOGY; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; HYGIENE; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PEPTIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; SUGARS; TRAPPING; VINEGAR; WINE

Analogy oligonukleotid obecn ho vzorce I a zp soby jejich v²roby a jejich pou it jako inhibitor exprese gen (antisense-oligonukleotid , ribozym , sense-oligonukleotid a oligonukleotid tvo° c ch triplexy), jako sond pro d kazy nukleov²ch kyselin a jako pomocn²ch l tek v molekul rn biologii. Popisuje se rovn pou it t chto slou enin pro l en onemocn n , kter jsou zp sobovan viry, kter jsou ovlivn na integriny nebo adhezn mi receptory bu ka-bu ka, nebo kter jsou zp sobena faktory jako je TNF-alfa, nebo pro l en rakoviny nebo resten zy.\ The present invention relates to oligonucleotide analogs of the general formula I, processes of their preparation as well as their use as gene expression inhibitors (antisense oligonucleotides, ribozymes, sense oligonucleotides and triplex-forming oligonucleotides), as probes for the detection of nucleic acids and as auxiliaries in molecular biology. there is also described the use of these compounds for treating virus-induced diseases and being influenced by integrins or adhesive receptors of cell-cell type or that are caused by factors such as TNF-alpha factor or for treating cancer or restenosis.