Polycyclic macrocycles containing pyrrole with directly bound steroidal substituents in meso positions

• Main Authors: POUZAR VLADIMIR RNCSC, URBANSKY MAREK RNCSC, DUKH MYKHAYLO CSC, KRAL VLADIMIR RNDOC. CSC, CERNY IVAN RNCSC, DRASAR PAVEL RNCSC
• Format: Patent
• Language: Czech; English
• Published: 14.08.2002
• Edition: 7
• Subjects: ADHESIVES; CHEMISTRY; DYES; HETEROCYCLIC COMPOUNDS; LAKES; METALLURGY; MISCELLANEOUS APPLICATIONS OF MATERIALS; MISCELLANEOUS COMPOSITIONS; MORDANTS; NATURAL RESINS; ORGANIC CHEMISTRY; ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES; PAINTS; POLISHES; STEROIDS

Polycyklick makrocykly, kter²mi jsou meso-tetrasteroidylporfyrinogeny obecn ho vzorce I, kde R a X jsou r zn , R jsou steroidn substituenty s bo n m °et zcem v poloze 17 a substituentem na skeletu vybran ze skupiny tvo°en homopregnany, dinor-cholestany, trinor-cholestany a cholov²mi kyselinami a X je atom vod ku nebo alkyl s po tem atom uhl ku 1 a 4 a meso-tetrasteroidylporfyriny obecn ho vzorce III, kde R m vp°edu uveden² v²znam. Slou eniny lze pou t pro v²robu p° pravk a v²robk maj c ch transportn a komplexa n schopnosti k iont m vybran²m ze skupiny jednomocn²ch a dvojmocn²ch kationt , halogen , fosf t a polyfosf t , a substr t m, vybran²m ze skupiny tvo°en sacharidy, aminokyselinami a oligonukleotidy a p°i p° prav analytick²ch senzor .\ In the present invention there are disclosed polycyclic macrocycles that are represented by meso-tetrasteroidyl porphyrinogens of the general formula I, in which R and X are different, whereby R represents steroidal substituents with a side chain in position 17 and a substituent on the skeleton being selected from the group comprising homopregnanes, dinor-cholestanes, trinor-cholestanes and cholic acids and X represents a hydrogen atom or alkyl containing 1 to 4 carbon atoms and meso-tetrasteroidyl porphyrins of the general formula III, wherein R is as specified above. These compounds can be used for preparing preparations and articles exhibiting transport and complexing capabilities to ions being selected from the group comprising monovalent and bivalent cations, halogens, phosphates and polyphosphates, and to substrates being selected from the group comprising saccharides, amino acids, and oligo nucleotides and for preparing analytic sensors.