Process for preparing hydrochloride of 5-amino-1,3-dimethyltricyclo(3,3,1,1 3,7 )decane

In the present invention there is disclosed a process for preparing memantine by reacting 5-chloro-1,3-dimethyltricyclo(3,3,1,1e3,7)decane with formamide. The preparation process is characterized by extraction of intermediates after reaction in toluene and subsequent treatment with hydrogen chloride...

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Bibliographic Details
Main Authors KYSILKA VLADIMIR RNCSC, PALASOVA LENKA, BYSTRA DAGMAR, ZIZKOVA V–RA RNDR
Format Patent
LanguageEnglish
Published 13.06.2001
Edition7
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:In the present invention there is disclosed a process for preparing memantine by reacting 5-chloro-1,3-dimethyltricyclo(3,3,1,1e3,7)decane with formamide. The preparation process is characterized by extraction of intermediates after reaction in toluene and subsequent treatment with hydrogen chloride, whereby memantine is extracted and minor products are selectively converted to the starting 5-chloro-1,3-dimethyltricyclo(3,3,1,1e3,7)decane.
Bibliography:Application Number: CZ19960001813