Derivatives of 2,3-dihydro-1,4-benzodioxin-5-yl-piperazine with 5-HT1A-antagonistic activity, process of their preparation and preparations in which those compounds are comprised as active components

• Main Authors: SCHIPPER JACQUES, VAN STEEN BARTHOLOMEUS JOHANNES, MOS JOHANNES, HARTOG JAN
• Format: Patent
• Language: English
• Published: 12.04.2000
• Edition: 7
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

In the present invention there are described 2,3-dihydro-1,4-benzodioxin-5-yl-piperazine derivatives of the general formula 2, as well as their salts exhibiting antagonist activity on 5-HTi1A and being therefore suitable for treating disorders of central nervous system. In the above indicated general formula Ri1 represents a halogen, alkyl containing 1 to 4 carbon atoms or alkoxyl having 1 to 4 carbon atoms a hydroxy group, a trifluoromethyl or cyano group, m is either 1 or 2, n is either 0 or 1, A represents an alkylene chain containing 2 to 6 carbon atoms being optionally substituted with a phenyl group and B represents methylene, ethylene, carbonyl, sulfinyl or sulfonyl or a sulfur atom. In the present invention there are also described processes for preparing the above specified derivatives and preparations in which they are comprised a active substances.