DERIVATIVE OF OXOQUINOLINECARBOXYLIC ACID, PROCESS OF ITS PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING THEREOF

• Main Authors: SCHMITGES CLAUS J. DR, MEDERSKI WERNER DR, CLAUDIA WILM DR, OSSWALD MATHIAS DR, DORSCH DIETER DR, CHRISTADLER MARIA
• Format: Patent
• Language: English
• Published: 12.02.1997
• Edition: 6
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Quinoline derivs. of formula (I) and their salts are new. R = R7 and R'+R" = O; or R+R' = bond and R" = OR7 or R8; R1 = Ar; R2 = COOR6, (CH2)nCOOR6, CN, 1H-tetrazol-5-yl or CONHSO2Ar; R3-R5 = R6, OR6, S(O)mR6, halo, NO2, NR6R61, NHCOR6, NHSO2R6, OCOR6, COR6, COOR6 or CN; or R3+R4 = O(CH2)nO; R6, R61 = H, 1-6C alkyl, CH2Ph or Ph; R7 = (CH2)nAr; R8 = Ar or OAr; Ar = Ph (opt. mono-, di- or trisubstd. by R9-R11), naphthyl, or a gp. of formula (a) or (b); R9-R11 = R6, OR6, halo, CF3, OCF3, OCHF2, OCH2F, NO2, NR6R61, NHCOR6, CN, NHSO2R6, COOR6, COR6, CONHSO2Ar, O(CH2)nR2, O(CH2)nOR6 or S(O)mR6; E = CH2, S or O; D = carbonyl or (C(R6R61))n; X = O or S; halo = F, Cl, Br or I; m = 0-2; n = 1-3.