HETEROCYCLYLBENZOYL GUANIDINE, PROCESS OF ITS PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING THEREOF

Heterocyclic benzoylguanidine cpds. of formula (I) and their salts are new. R1 = A, CF3, CH2F, CHF2, CN, C2F5, NO2, halo, C IDENTICAL CH or XR4; R2, R3 = H, halo, A, XR4, CN, NO2, CF3, CH2F, CHF2, C2F5, CH2CF3, SOnR6, SO2NR4R5, Ph or OPh; R4 = H, A, 5-7C cycloalkyl, 6-8C cycloalkylmethyl, CF3, CH2F,...

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Bibliographic Details
Main Authors GERICKE ROLF DR, BAUMGARTH MANFRED DR, DORSCH DIETER DR, BEIER NORBERT DR, MINCK KLAUS OTTO DR
Format Patent
LanguageEnglish
Published 14.08.1996
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Heterocyclic benzoylguanidine cpds. of formula (I) and their salts are new. R1 = A, CF3, CH2F, CHF2, CN, C2F5, NO2, halo, C IDENTICAL CH or XR4; R2, R3 = H, halo, A, XR4, CN, NO2, CF3, CH2F, CHF2, C2F5, CH2CF3, SOnR6, SO2NR4R5, Ph or OPh; R4 = H, A, 5-7C cycloalkyl, 6-8C cycloalkylmethyl, CF3, CH2F, CHF2, CH2CF3, Ph or CH2Ph; R5 = H or A; or R4+R5 = 4-5C alkylene, opt. with one CH2 replaced by O, S, NH, NA or NCH2Ph; R6 = A or Ph; Het = one or two-ringed heterocycle (satd., unsatd. or aromatic) with 1-4 N, O and/or S, bonded at N or C and opt. mono- tri-substd. with halo, CF3, A, XR4, CN, NO2 and/or carbonyloxy (sic); A = 1-6C alkyl; X = O, S or NR5; Ph = phenyl, opt. mono- to tri-substd. by A, OA, NR4R5, halo or CF3; halo = F, Cl, Br or I; n = 1-2
Bibliography:Application Number: CZ19950002202