6,8-Disubstituted-9-(heterocyclyl)purines, compositions containing these derivatives and their use in cosmetic and medicinal applications

• Main Authors: Voller Jiří, Kadlecová Alena, Grúz Jiří, Strnad Miroslav, Doležal Karel, Zatloukal Marek, Nisler Jaroslav, Zahajská Lenka
• Format: Patent
• Language: Czech; English
• Published: 22.06.2016
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BEER; BIOCHEMISTRY; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; FISHING; FORESTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HUNTING; HYGIENE; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS; SPIRITS; TRAPPING; VINEGAR; WINE

Řešení poskytuje 6,8-disubstituované-9-(heterocyklyl)puriny vzorce I, které jsou použitelné pro přípravu léčebných a kosmetických přípravků a kompozic. 6,8-Disubstituované-9-(heterocyklyl)puriny podle tohoto vynálezu vykazují řadu biologických aktivit, zejména antioxidační, antiinflamatorní a antisenescenční, ale i další aktivity použitelné v kosmetických a farmaceutických aplikacích. 6,8-Disubstituované-9-(heterocyklyl)puriny obecného vzorce I vykazují dále účinky růstově-regulační, diferenciační, proliferační a proti stárnutí na úrovni buněk, tkání i celých rostlinných, savčích i lidských organizmů. 6,8-Disubstituted-9-(heterocyclyl)purines for use in pharmaceutical and cosmetic compositions and applications are provided. These 6,8-disubstituted-9-(heterocyclyl)purines have a wide range of biological activities, including for example antioxidant, anti-inflammatory, anti-senescent, anti-aging, as well as well as other activities which are especially useful in pharmaceutical and cosmetic applications. Compositions may include additional excipients and auxiliary substances. Methods of treatment of animals, mammals, plants, cells, yeast, and cells in tissue culture are also disclosed.