Process for the preparation of tablets from pharmaceutically active substances having unfavorable tabletting properties with granulating liquid comprising microcrystalline cellulose

The invention refers to a process for the preparation of tablets that can be well compressed and have good mechanical strength from pharmaceutically active ingredient(s) having unfavourable tabletting properties. In the process of the invention a granulating liquid is used which is a suspension of 5...

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Bibliographic Details
Main Author JAMBOR ISTVANNE
Format Patent
LanguageCzech
English
Published 16.03.2005
Edition7
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The invention refers to a process for the preparation of tablets that can be well compressed and have good mechanical strength from pharmaceutically active ingredient(s) having unfavourable tabletting properties. In the process of the invention a granulating liquid is used which is a suspension of 5-30% of microcrystalline cellulose-90% of which have a particle size that is lower than 50 Sg(m)m, and the amount of the microcrystalline cellulose refers to the final tablet mass in water and/or ethanol and/or isopropanol, and said suspension may contain also a part of the ingredients of the granules in dissolved form.
Bibliography:Application Number: CZ20040001145