Farnesyl transferase inhibitors

Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.

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Bibliographic Details
Main Authors LIN NAN-HORNG, HASVOLD LISA A, SHAM HING L, TONG YUNSONG, WANG GARY T, ROCKWAY TODD W, WANG LE, WANG WEIBO, GWALTNEY STEPHEN L. II, LI QUN, LI TOMGMEI, SULLIVAN GERARD M, WANG XILU, CLAIBORNE AKIYO K, MANTEL ROBERT A
Format Patent
LanguageCzech
English
Published 12.11.2003
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.
Bibliography:Application Number: CZ20030001804