2,8-DISUBSTITUTED QUINAZOLINES, PROCESS OF THEIR PREPARATION, PHARMACEUTICAL COMPOSITION SUCH COMPOUNDS AND THEIR USE

• Main Authors: PERZBORN ELISABETH DR, SCHUTZ HELMUTH DR, HEIKER FRED ROBERT DR, SCHRAMM MATTHIAS DR, BISCHOFF ERWIN DR, NIEWOHNER ULRICH DR, HARTWIG WOLFGANG DR
• Format: Patent
• Language: English
• Published: 14.08.1996
• Edition: 6
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

2,8-Disubstd. quinazolinones of formula (I) and their tautomers and salts are new: A = oxiranyl opt. substd. by 1-8C alkyl or phenyl (1-8C) alkyl; -C(R1)=CHR2; -CH(R3)LR4; or -CH2R5; R1 = H or 1-6C alkyl; R2 = 1-8C alkyl or phenyl (1-8C) alkyl; R3 = 1-5C alkyl or OR6; R6 = H, a protecting gp. or 1-5C alkyl; R4 = 2-10C alkyl or phenyl (2-10C) alkyl; L = CO, CHOH, CH2 or CHOSO2R7; R7 = 1-4C alkyl or phenyl; R5 = 3-8C alkyl, phenyl (3-8C) alkyl, benzyl or 2-phenylethyl; D = H or SO2NR8R9; R8 and R9 = H, phenyl, 1-6C alkyl or 1-6C hydroxyalkyl, or NR8R9 is a 5- or 6-membered satd. ring which contains 0-2 further heteroatoms (S, N and/or O) and is opt. substd. via free N function by 1-6C alkyl or hydroxyalkyl; E = 1-8C alkyl.