PROCESS FOR PREPARING "SYN" PROPANAMIDE DERIVATIVES

Method for preparing a 'syn' derivative of propanamide of forumula (I) by the action of a derivative of camphosultam of general formula (II) or (III) on aldehyde of formula (IV) in the presence of a Lewis acid and an organic base. In formulae (I) to (IV), X is a halogen atom, R is an alkyl...

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Bibliographic Details
Main Authors RADISSON XAVIER, AUBERT THIERRY
Format Patent
LanguageEnglish
Published 16.02.1994
Edition5
Subjects
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Method for preparing a 'syn' derivative of propanamide of forumula (I) by the action of a derivative of camphosultam of general formula (II) or (III) on aldehyde of formula (IV) in the presence of a Lewis acid and an organic base. In formulae (I) to (IV), X is a halogen atom, R is an alkyl, aryl or heteroaryl radical, R1? is the residue of one or other of the camphosultam enantiomers. The products obtained by the method may be used in the preparation of therapeutically active products.
Bibliography:Application Number: CS19930001153