ΔΙΕΡΓΑΣΙΑ ΓΙΑ ΤΗΝ ΠΑΡΑΣΚΕΥΗ [(5-(3-ΧΛΩΡΟΦΑΙΝΥΛ)-3-ΥΔΡΟΞΥΠΥΡΙΔΙΝΟ-2-ΚΑΡΒΟΝΥΛ)-ΑΜΙΝΟ]ΟΞΙΚΟΥ ΟΞΕΟΣ ΑΠΟ 5-((3-ΧΛΩΡΟΦΑΙΝΥΛ)-3-ΧΛΩΡΟ-ΠΥΡΙΔΙΝ-2-ΥΛ)-ΝΙΤΡΙΛΙΟ, ΚΑΙ ΔΙΕΡΓΑΣΙΑ ΓΙΑ ΤΗΝ ΠΑΡΑΣΚΕΥΗ ΠΑΡΑΓΩΓΩΝ 5-((ΑΛΟΓΟΝΟΦΑΙΝΥΛ)-3-ΑΛΟΓΟΝΟ-ΠΥΡΙΔΙΝ-2-ΥΛ)-ΝΙΤΡΙΛΙΟΥ

• Main Authors: JANUSZ, John, Michael, DIXON, Craig, Edward, COPP, James, Densmore, OUDENES, Jan, LANTHIER, Christopher, M, GORIN, Boris, LU, Alan, Qingbo
• Format: Patent
• Language: Greek
• Published: 25.11.2022
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Μια διεργασία για την παρασκευή της ένωσης (5): The present invention relates to a process for preparing N-[[5-(3- chlorophenyl)-3-hydroxy-2-pyridinyl]carbonyl]-glycine (compound (5)), from the intermediates 5-(3-chlorophenyl)-3-chloro-2- pyridinecarbonitrile (compound (1)), 5-(3-chlorophenyl)-3-methoxy-2- pyridinecarbonitrile (compound (2)), 5-(3-chlorophenyl)-3-hydroxy-2- pyridinecarboxylic acid (compound (3)). Compound (5) is an intermediate in the preparation of prolyl hydroxylase inhibitors.