ΥΠΟΚΑΤΕΣΤΗΜΕΝΑ ΜΕ ΕΤΕΡΟΑΡΥΛΙΟ ΑΜΙΔΙΑ ΤΑ ΟΠΟΙΑ ΠΕΡΙΕΧΟΥΝ ΜΙΑ ΚΕΚΟΡΕΣΜΕΝΗ ΟΜΑΔΑ ΣΥΝΔΕΤΗ ΚΑΙ Η ΧΡΗΣΗ ΤΟΥΣ ΩΣ ΦΑΡΜΑΚΑ

• Main Authors: ZOLLER GERHARD, STROBEL HARTMUT, WOHLFART PAULUS, WILL DAVID WILLIAM
• Format: Patent
• Language: Greek
• Published: 13.04.2016
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

Η παρούσα εφεύρεση σχετίζεται με Ν-αλκυλαμίδια με τον τύπο I, The present invention relates to N-alkylamides of the formula I, in which A, Het, X, R 1 , R 2 and R 3 have the meanings indicated in the claims, which modulate the transcription of endothelial nitric oxide (NO) synthase and are valuable pharmacologically active compounds. Specifically, the compounds of the formula I upregulate the expression of the enzyme endothelial NO synthase and can be applied in conditions in which an increased expression of said enzyme or an increased NO level or the normalization of a decreased NO level is desired. The invention further relates to processes for the preparation of compounds of the formula I, to pharmaceutical compositions comprising them, and to the use of compounds of the formula I for the manufacture of a medicament for the stimulation of the expression of endothelial NO synthase or for the treatment of various diseases including cardiovascular disorders such as atherosclerosis, thrombosis, coronary artery disease, hypertension and cardiac insufficiency, for example.