TRIAZOLOBENZAZEPINAS COMO ANTAGONISTAS DEL RECEPTOR V1A DE LA VASOPRESINA

• Main Authors: Vukics, Krisztina, Baska, Ferenc, Bozó, Éva, Szondiné Kordás, Krisztina, Bata, Imre
• Format: Patent
• Language: Spanish
• Published: 12.12.2022
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

La presente invención se refiere a un compuesto de fórmula general (I) (ESPACIO PARA LA FÓRMULA) útil en el tratamiento y/o profilaxis de una enfermedad o afección asociada con la función del receptor V1a. The present invention relates to 5,6-dihydro-4H-[1,2,4]triazolo[4,3-a][1]benzazepine derivatives of general formula (I) and/or salts thereof and/or geometric isomers thereof and/or stereoisomers thereof and/or enantiomers thereof and/or racemates thereof and/or diastereomers thereof and/or biologically active metabolites thereof and/or prodrugs thereof and/or solvates thereof and/or hydrates thereof and/or polymorphs thereof which are centrally and/or peripherally acting V1a receptor modulators, particularly V1a receptor antagonists. Additional subject of the present invention is the process for the preparation of the compounds and the intermediates of the preparation process as well. The invention also relates to the pharmaceutical compositions containing the compounds or together with one or more other active substances, as well as to the use in the treatment and/or prophylaxis of a disease or condition associated with V1a receptor function.