MODULADORES DE PIRROLOPIRIDINA DE RORC2 SUSTITUIDOS CON METILO Y TRIFLUOROMETILO

La presente invención proporciona pirrolopiridinas sustituidas con metilo y trifluorometilo, ESPACIO PARA LA FÓRMULA útiles en el tratamiento de enfermedades inflamatorias y trastornos del sistema inmunitario. The present invention provides methyl- and trifluoromethyl-substituted pyrrolopyridines, p...

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Main Authors Wennerstål, Göran Mattias, Xing, Li, Kaila, Neelu, Vazquez, Michael L, Schnute, Mark Edward, Zamaratski, Edouard, Mente, Scot Richard, Trzupek, John David, Jones, Peter, Flick, Andrew Christopher, Zhang, Liying
Format Patent
LanguageSpanish
Published 03.05.2019
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:La presente invención proporciona pirrolopiridinas sustituidas con metilo y trifluorometilo, ESPACIO PARA LA FÓRMULA útiles en el tratamiento de enfermedades inflamatorias y trastornos del sistema inmunitario. The present invention provides methyl- and trifluoromethyl-substituted pyrrolopyridines, pharmaceutical compositions thereof, methods of modulating RORγ activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such pyrrolopyridines and pharmaceutical compositions thereof.
Bibliography:Application Number: CU20170000018