METHOD OF 2-GUANIDINOTHIAZOLE'S DERIVATIVE PRODUCTION

A method for preparing 2-guanidinothiazole derivs. of formula (I) comprises (A) reacting amidinothiourea of formua (II) with 1,3dihaloacetone to produce a cpd. of formula (III) (B) and then reacting (III) with thiourea in the pressence of water. In the formulas, Y is -C(NH2)NH; X is halogen. (I) act...

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Main Authors BOD PETER,HU, HARSANYI KALMAN ,HU, BOGSCH ERIK ,HU, CSONGOR AGAINE EVA ,HU, TRISCHLER FERENC DR.,HU
Format Patent
LanguageEnglish
Published 12.07.1989
Edition4
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Summary:A method for preparing 2-guanidinothiazole derivs. of formula (I) comprises (A) reacting amidinothiourea of formua (II) with 1,3dihaloacetone to produce a cpd. of formula (III) (B) and then reacting (III) with thiourea in the pressence of water. In the formulas, Y is -C(NH2)NH; X is halogen. (I) active against gastric acid secretion.
Bibliography:Application Number: CS19870008101