STRAIN OF "PENICILLIUM CHRYSOGENUM CCM 8013" MICROORGANISM

The aim of the invention is to acquire the strain producing penicillin in higher concentrates that with previous strains. Penicillin is synthesised by the mutant Penicillium chrysogenum, acquired after the action of the selected mutagens and after passive selections, in a medium containing a suitabl...

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Main Authors OKANIK BORIS ,CS, MATELOVA VLASTA RNCSC.,CS, PILAT PETR CSC.,CS, MIKLAS EMIL ,CS, BUCKO MICHAL CSC.,CS, ULEHLOVA MIROSLAVA ,CS, BEZDEK KAREL ,CS
Format Patent
LanguageEnglish
Published 12.03.1991
Edition5
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROCESSES USING MICROORGANISMS
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:The aim of the invention is to acquire the strain producing penicillin in higher concentrates that with previous strains. Penicillin is synthesised by the mutant Penicillium chrysogenum, acquired after the action of the selected mutagens and after passive selections, in a medium containing a suitable source of carbon, nitrogen, sulphur, phosphorus and trace elements, chalk, a precursor of the side-chain of penicillin and the defoamer, at high conversion of the source of carbon, under aerobic conditions at 25 degrees C. In the course of 168 hours cultivation in laboratory conditions this strain forms 35,300 j of penicillin V per 1 ml.
Bibliography:Application Number: CS19870008424