METHOD OF PRODUCING DERIVATIVES OF 3-/1-PYRAZOLYL/-PYRIDAZINE

3-(1-Pyrazolyl)-pyridazine derivatives of the formula I, or pharmaceutically acceptable acid addition salts thereof, which decrease high blood pressure and inhibit catabolism or prostaglandins, (I) wherein R1 is hydrogen or C1-4 alkyl, R2 is hydrogen, cyano, carboxyl, carbamoyl, carbaxoyl or C1-4 al...

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Main Authors POLGARI,ISTVAN,HU, ELEK,SANDOR,HU, ELEKES,ISTVAN,HU, SZILAGYI,GEZA,HU, DIVALD,ANDRAS,HU, CSEH,GYOERGY,HU, TOLNAY,PAL,HU, KASZTREINER,ENDRE,HU, KOSA,EDIT,HU, JASZLITS,LASZLO,HU, TARDOS,LASZLO,HU
Format Patent
LanguageEnglish
Published 31.03.1981
Edition3
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:3-(1-Pyrazolyl)-pyridazine derivatives of the formula I, or pharmaceutically acceptable acid addition salts thereof, which decrease high blood pressure and inhibit catabolism or prostaglandins, (I) wherein R1 is hydrogen or C1-4 alkyl, R2 is hydrogen, cyano, carboxyl, carbamoyl, carbaxoyl or C1-4 alkoxycarbonyl, R3 is hydrogen or chlorine or -NR4NHR5 or NR6R7, wherein R4 and R5 are each hydrogen or C1-4 alkyl, wherein R6 and R7 are each hydrogen or C1-5 alkyl, C1-5 hydroxyalkyl, C3-7 cycloalkyl, phenyl or benzyl, or benzyl or phenylethyl substituted with one or two chlorine atoms or methoxy groups, or a furylmethyl, pyridylmethyl, pyrrolidine or piperazine ring, or when R7 is hydrogen, R6 is -(CH2)n -NR4R5 wherein n is an integer from 1 to 3.
Bibliography:Application Number: CS19780003783