ANTICUERPOS MONOCLONALES HUMANOS DE CTLA-4

• Main Authors: JEFFERY HERBERT HANKE, STEVEN CHRISTOPHER GILMAN, DOUGLAS CHARLES HANSON, GEOFFREY DAVIS C, JOSE RAMON CORVALAN, MARK JOSEPH NEVEU, EILEEN ELLIOT MUELLER
• Format: Patent
• Language: Spanish
• Published: 17.01.2005
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BEER; BIOCHEMISTRY; CARE OF BIRDS, FISHES, INSECTS; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; NEW BREEDS OF ANIMALS; NEW PLANTS OR PROCESSES FOR OBTAINING THEM; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; TRAPPING; VINEGAR; WINE

DE ACUERDO CON LA PRESENTE INVENCION SE PROPORCIONAN ANTICUERPOS NONOCLONALES TOTALMENTE HUMANOS CONTRA EL ANTIGENO 4 CITOTOXICO HUMANO LINFOCITO T (CTLA-4). SE PROPORCIONAN SECUENCIAS DE NUCLEOTIDOS CODIFICANTES Y LAS SECUENCIAS DE AMINOACIDOS QUE COMPRENDEN MOLECULAS DE INMUNOGLOBULINA DE CADENA LIGERA, PARTICULARMENTE SECUENCIAS CONTINUAS DE CADENA PESADA Y LIGERA QUE SE EXPANDEN EN LAS REGIONES DETERMINADORAS DE COMPLEMENTARIDAD (CDR), ESPECIFICAMENTE DE ENTRE FR1 Y/O CDR1N HASTA CDR3 Y/O DENTRO DE FR4, TAMBIEN SE PROPORCIONAN ANTICUERPOS U OTROS ANTAGONISTAS QUE TIENEN FUNCIONALIDADES SIMILARES COMO ANTICUERPOS. In accordance with the present invention, there are provided fully human monoclonal antibodies against human cytotoxic T-lymphocyte antigen 4 (CTLA-4). Nucleotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, particularly contiguous heavy and light chain sequences spanning the complementarity determining regions (CDRs), specifically from within FR1 and/or CDR1 through CDR3 and/or within FR4, are provided. Further provided are antibodies having similar binding properties and antibodies (or other antagonists) having similar functionality as antibodies disclosed herein.