ANNULATED 2-AMINO-3-CYANO THIOPHENES AND DERIVATIVES FOR THE TREATMENT OF CANCER

, A, p, U, V and W have the meanings given in the claims and specification, their use as inhibitors of KRAS, pharmaceutical compositions and preparations containing such compounds and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases....

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Main Authors MANTOULIDIS, Andreas, SARKAR, Dhruba, TREU, Matthias, LITTLE, Andrew, PHAN, Jason, SMETHURST, Christian Alan Paul, BROEKER, Joachim, SOKOL, Kevin, STADTMUELLER, Heinz, WILDING, Birgit, SUN, Qi, CUI, Jianwen, FUCHS, Julian, RAMHARTER, Juergen, WATERSON, Alex, HERDEIS, Lorenz, FESIK, Stephen W, WUNBERG, Tobias, ABBOTT, Jason, HODGES, Tim, GOLLNER, Andreas
Format Patent
LanguageEnglish
Spanish
Published 17.07.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:, A, p, U, V and W have the meanings given in the claims and specification, their use as inhibitors of KRAS, pharmaceutical compositions and preparations containing such compounds and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases. La presente invención abarca compuestos de la Fórmula (I) , en donde R1a, R1b, R2a, R2b, Z, R3 a R5, A, p, U, V y W tienen los significados dados en las reivindicaciones y la memoria descriptiva, su uso como inhibidores de KRAS, composiciones farmacéuticas y preparaciones que contienen dichos compuestos y su uso como medicamentos/usos médicos, especialmente como agentes para el tratamiento y/o la prevención de enfermedades oncológicas.
Bibliography:Application Number: CR20240000233