NLRP3 INFLAMMASOME INHIBITORS

, W, X, Y, and Z have the meanings defined herein. Such compounds are useful in inhibiting NLRP3 inflammasome activity and may be useful as therapeutic agents. The specification also relates to the use of such compounds to treat or prevent diseases and conditions in which the NLRP3 inflammasome is i...

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Bibliographic Details
Main Authors BERGONZINI, Giulia, GRADÉN, Henrik, MATSUMURA, Takehiko, JOHANSSON, Lars Anders Mikael, SUGAMA, Hiroshi
Format Patent
LanguageEnglish
Spanish
Published 24.05.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:, W, X, Y, and Z have the meanings defined herein. Such compounds are useful in inhibiting NLRP3 inflammasome activity and may be useful as therapeutic agents. The specification also relates to the use of such compounds to treat or prevent diseases and conditions in which the NLRP3 inflammasome is implicated. The specification further relates to compositions comprising such compounds. La memoria descriptiva se refiere en general a compuestos de fórmula (I) y sales farmacéuticamente aceptables de los mismos, donde R , R , R , R , R , W, X, Y y Z tienen los significados definidos en el presente documento. Dichos compuestos son útiles para inhibir la actividad del inflamasoma NLRP3 y pueden ser útiles como agentes terapéuticos. La memoria descriptiva también se refiere al uso de dichos compuestos para tratar o prevenir enfermedades y afecciones en las que está implicado el inflamasoma NLRP3. La memoria descriptiva se refiere además a composiciones que comprenden dichos compuestos.
Bibliography:Application Number: CR20240000038