PYRAZOLE DERIVATIVES AS RET KINASE INHIBITORS

Disclosed herein are compounds of formula I: or a pharmaceutically acceptable salt thereof, where the variables are as defined herein. These compounds are useful in treating RET associated cancers. Formulations containing the compounds of formula I and methods of making the compounds of formula I ar...

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Main Authors MCFADDIN, Elizabeth, A, ANDREWS, Steven, W, ANDERSON, Erin, D, MCKENNEY, Megan, L, MCLEAN, Johnathan, Alexander, KOLAKOWSKI, Gabrielle, R., a/k/a Jody, Gabrielle, Rustmann, KOLAKOWSKI, MUNCHHOF, Michael, J, PANCALDI, Thomas, Pierre, Dino, KUMAR, Manoj, CONDROSKI, Kevin, R, BOLDRON, Christopher, Pierre, Albert, Jean, PINTO, Marta, PILKINGTON-MIKSA, Michael Alexander, IRVIN, Thomas, C, MOURET, Tiphaine
Format Patent
LanguageEnglish
Spanish
Published 03.07.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed herein are compounds of formula I: or a pharmaceutically acceptable salt thereof, where the variables are as defined herein. These compounds are useful in treating RET associated cancers. Formulations containing the compounds of formula I and methods of making the compounds of formula I are also disclosed. En la presente descripción se describen compuestos de Fórmula I: o una sal farmacéuticamente aceptable de este, donde las variables son como se definen en la presente descripción. Estos compuestos son útiles en el tratamiento de cánceres asociados a RET. También se describen formulaciones que contienen los compuestos de Fórmula I y métodos para preparar los compuestos de Fórmula I.
Bibliography:Application Number: CR20230000193