PROTEINS COMPRISING KALLIKREIN RELATED PEPTIDASE 2 ANTIGEN BINDING DOMAINS AND THEIR USES

Embodiments of the present invention provide isolated proteins comprising antigen binding domains that bind kallikrein related peptidase 2 (hK2), including monospecific and bispecific antibodies. Additional embodiments of the invention provide polynucleotides encoding the hk2-specific proteins, vect...

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Main Authors MCDEVITT, Theresa, SINGH, Sanjaya, LUO, Jinquan, ZHAO, Yonghong, SHEN, Fei, YI, Fang, BRITTINGHAM, Raymond, SONG, Degang, LEE, John, GANESAN, Rajkumar, VENKATARAMANI, Sathyadevi, LA PORTE, Sherry Lynn
Format Patent
LanguageEnglish
Spanish
Published 04.05.2022
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Embodiments of the present invention provide isolated proteins comprising antigen binding domains that bind kallikrein related peptidase 2 (hK2), including monospecific and bispecific antibodies. Additional embodiments of the invention provide polynucleotides encoding the hk2-specific proteins, vectors, host cells, and methods of making and using them. Las modalidades de la presente invención proporcionan proteínas aisladas que comprenden dominios de unión al antígeno que se unen a la peptidasa 2 relacionada con la calicreína (hK2), que incluyen anticuerpos monoespecíficos y biespecíficos. Las modalidades adicionales de la invención proporcionan polinucleótidos que codifican las proteínas, vectores, células huésped específicas de hk2, y métodos para elaborarlos y usarlos.
Bibliography:Application Number: CR20220025