METHODS OF TREATING CANCER

Therapeutic methods and pharmaceutical compositions for treating cancer including a myeloproliferative neoplasm (MPN), including polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis in a human subject are described. In certain embodiments, the invention includes therapeu...

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Bibliographic Details
Main Author ROTHBAUM, Wayne
Format Patent
LanguageEnglish
Spanish
Published 30.04.2021
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Therapeutic methods and pharmaceutical compositions for treating cancer including a myeloproliferative neoplasm (MPN), including polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis in a human subject are described. In certain embodiments, the invention includes therapeutic methods of treating a MPN using a MDM2 inhibitor of Formula (I) or Formula (II). Se describen métodos terapéuticos y composiciones farmacéuticas para tratar cáncer incluido un neoplasma mieloproliferativo (MPN), incluido policitemia vera (PV), trombocitemia esencial (ET), y mielofibrosis primaria en un sujeto humano. En ciertas modalidades, la invención incluye métodos para tratar una MPN utilizando un inhibidor de MDM2 de la Fórmula (I) o Fórmula (II).
Bibliography:Application Number: CR20200000576