HETEROCYCLIC COMPOUNDS USEFUL AS DUAL ATX/CA INHIBITORS

• Main Authors: HERT, Jérôme, GOMME, Justin, RUDOLPH, Markus, DI GIORGIO, Patrick, MATTEI, Patrizio, SCHMITZ, Petra, HUNZIKER, Daniel
• Format: Patent
• Language: English; Spanish
• Published: 01.11.2019
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

La invención proporciona nuevos compuestos que tienen la fórmula general (I)(I) en la que R1, R2, Y, X, W, m y n son como se definen en el presente documento, composiciones que incluyen los compuestos y métodos de uso de los compuestos.The invention provides novel compounds having the general formula (I) wherein R1 is selected from substituted phenyl, pyridinyl or thiophenyl, R2 is selected from optionally substituted aminosulphonylphenyl, aminosulphonylpyridinyl, aminosulphonylthiophenyl or aminosulphonylthiazolyl, X is nitrogen or carbon, Y is a linking group, Z is a direct bond or a linking group, m = 0-5, n = 0-5 with the proviso that m+n is 2-5, compositions including the compounds and the use of the compounds in the treatment or prophylaxis of ocular conditions. The invention provides novel compounds having the general formula (I)wherein R1, R2, Y, X, W, m and n are as defined herein, compositions including the compounds and methods of using the compounds.