UNA FORMA CRISTALINA Y AMORFA DE GENZ 112638 HEMITARTRATO COMO INHIBIDORES DE GLUCOSILCERAMIDA SINTASA

Se desvela la sal de hemitartrato de un compuesto representado por la fórmula estructural, que puede utilizarse en aplicaciones farmacéuticas. Las formas cristalinas únicas particulares de Hemitartrato de formúla (I) se caracterizan por una variedad de propiedades y mediciones físicas. The hemitartr...

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Main Authors WILLIS, CHRIS, BHARDWAJ, RENU, MARSHALL, JOHN, COPELAND, DIANE, P, PALACE, GERARD, SKELL, JEFFREY, KOCHLING, JIANMEI, LIU, HARLIN, SIEGEL, CRAIG, PETERSCHMITT, JUDITH, HARIANAWALA, ABIZER, CHENG, SENG
Format Patent
LanguageSpanish
Published 05.09.2012
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Se desvela la sal de hemitartrato de un compuesto representado por la fórmula estructural, que puede utilizarse en aplicaciones farmacéuticas. Las formas cristalinas únicas particulares de Hemitartrato de formúla (I) se caracterizan por una variedad de propiedades y mediciones físicas. The hemitartrate salt of a compound represented by the following structural formula:(Formula I Hemitartrate), which may be used in pharmaceutical applications, are disclosed. Particular single crystalline forms of the Formula (I) Hemitartrate are characterized by a variety of properties and physical measurements. As well, methods of producing crystalline Formula (I) Hemitartrate, and using it to inhibit glucosylceramide synthase or lowering glycosphingolipid concentrations in subjects to treat a number of diseases, are also discussed. Pharmaceutical compositions are also described.
Bibliography:Application Number: CR20120000277