DERIVADOS DE N-(HETERO)ARIL-PIRROLIDINA DE PIRAZO-4-IL-PIRROLO[2,3-D]PIRIMIDINAS Y PIRROL-3-IL-PIRROLO[2,3-D]PIRIMIDINAS COMO IHNIBIDORES DE LA QUINASA JANUS

La presente invención se relaciona con derivados de N-(hetero)aril-pirrolidina de fórmula (I); que son inhibidores de JAK, tal como inhibidores selectivos de JAK1, útiles en el tratamiento de enfermedades asociadas con JAK. The present invention relates to N-(hetero)aryl-pyrrolidine derivatives of F...

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Main Authors SHEPARD, STACEY, ARVANITIS, ARGYRIOS, G, WANG, HAISHENG, SHAO, LIXIN, FOLMER, BEVERLY, ZHU, WENYU, STORACE, LOUIS, RODGERS, JAMES, D, GLENN, JOSEPH P
Format Patent
LanguageSpanish
Published 02.02.2012
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:La presente invención se relaciona con derivados de N-(hetero)aril-pirrolidina de fórmula (I); que son inhibidores de JAK, tal como inhibidores selectivos de JAK1, útiles en el tratamiento de enfermedades asociadas con JAK. The present invention relates to N-(hetero)aryl-pyrrolidine derivatives of Formula I: which are JAK inhibitors, such as selective JAK1 inhibitors, useful in the treatment of JAK-associated diseases including, for example, inflammatory and autoimmune disorders, as well as cancer.
Bibliography:Application Number: CR20110000620