INHIBIDORES DE LA METALOPROTEINASA MATRIZ

• Main Authors: ARPITA MUSIB, SUNANDA G. DASTIDAR, ABDUL RCHNIAN ABDUL RAUF, VISWAJANANI J. SATTIGERI, AJAY SONI, PUNIT KUMAR SRIVASTAVA, VENKATA P. PALLE, MANOJ KUMAR KHERA, RANADHEER REDDY, SONY JOSEPH, MANOJ KUMAR TIWARI
• Format: Patent
• Language: Spanish
• Published: 30.04.2009
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

El presente invento se relacion con acidos carboxilicos sustituidos mediante B-hidroxi y amino, que actuan como inhibidores de la metaloproteasa matriz, acidos carboxilicos B-hidroxi diastereomericamente puros, procesos correspondientes para la sintesis de composiciones farmaceuticas que contienen los compuestos del presente invento. The present invention relates to ²-hydroxy and amino substituted carboxylic acids, which act as matrix metalloprotease inhibitors, particularly diastereomerically pure ²-hydroxy carboxylic acids, corresponding processes for the synthesis of and pharmaceutical compositions containing the compounds of the present invention. Compounds of the present invention are useful in the treatment of various inflammatory, autoimmune and allergic diseases, such as methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatic arthritis, psoriasis, pulmonary fibrosis, wound healing disorders, pulmonary inflammation, acute respiratory distress syndrome, perodontitis, multiple sclerosis, gingivitis, atherosclerosis, neointimal proliferation, which leads to restenosis and ischemic heart failure, stroke, renal diseases, tumor metastasis, and other inflammatory disorders characterized by the over-expression and over-activation of a matrix metalloproteinase using the compounds.