ACIDOS BIFENILOCARBOCILICOS SUBSTITUIDOS Y SUS DERIVADOS

• Main Authors: MIHIRO SUNOSE, SVENJA BURCKHARDT, ADELINE LEFORMAL, CYRILLE BOUSSARD, KATHRYN SMELT, VALERIE READER, YAN ZHANG, ALISON REID, FRANCIS WILSON, JESS TAYLOR, RICHARD JOHN HARRISON, JEREMY MAYOR, CHIH YUNG HO, REMEDIOS HERNANDEZ-PERNI, ANDREW CANSFIELD
• Format: Patent
• Language: Spanish
• Published: 31.03.2009
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

l o ester del mismo; mas aun, la invencion se relaciona con el uso de dichos compuestos para el tratamiento de la enfermedad de Alzheimer y con su uso para la modulacion de la actividad y-secretasa, en donde A es O, NH, S; X es un enlace o grupo -CR5R6 Y es un grupo carboxi-C(O)OH o un grupo tetrazol sustituido o no sustituido. The present invention relates to compounds having the general formula (I) with the definitions of X,Y and A given below, and/or a salt or ester thereof. Furthermore the invention relates to the use of said compounds for the treatment of Alzheimer's disease and their use for the modulation of ³-secretase activity. wherein A is O, NH, S; X is a bond or a group -CR 5 R 6 Y is a carboxy group -C(O)OH or a substituted or unsubstituted tetrazole group; and/or a salt or ester thereof.