Compuestos aromáticos que contienen boro y análogos de insulina

• Main Authors: MAHDAVI, Alborz, SHAKER, Mirna Ekram Anwar, STEELE, Jack Joseph, SPENCER, Ryan Kelly, LIANG, Jingxin, MALI, Sachitanand, CHEN, Diao
• Format: Patent
• Language: Spanish
• Published: 19.05.2023
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

La presente divulgación se refiere a nuevos compuestos que incluyen uno o más grupos aromáticos que contienen boro. La presente divulgación se refiere además a composiciones farmacéuticas que contienen tales compuestos, y su uso en la prevención y el tratamiento de trastornos, tales como hiperglucemia, diabetes tipo 2, intolerancia a la glucosa, diabetes tipo 1, obesidad, síndrome metabólico X o dislipidemia, diabetes durante el embarazo, prediabetes, enfermedad de Alzheimer, diabetes MODY 1, MODY 2 o MODY 3, trastornos del estado de ánimo y trastornos psiquiátricos. The present disclosure relates to novel compounds that include one or more aromatic boron-containing groups. The present disclosure further relates to pharmaceutical compositions containing such compounds, and their use in prevention and treatment of disorders, such as hyperglycemia, type 2 diabetes, impaired glucose tolerance, type 1 diabetes, obesity, metabolic syndrome X, or dyslipidemia, diabetes during pregnancy, pre-diabetes, Alzheimer's disease, MODY 1, MODY 2 or MODY 3 diabetes, mood disorders, and psychiatric disorders.