Inhibidores alostéricos de cromenona del fosfoinosítido 3-quinasa (pi3k) para el tratamiento de enfermedades asociadas con la modulación de p13k

• Main Authors: ANDERSON, Erin Danielle, GERASYUTO, Aleksey I, HICKEY, Eugene R, FENG, Shulu, KOLAKOWSKI, Gabrielle R, MCLEAN, Johnathan Alexander, SEVERANCE, Daniel Lee, WIDJAJA, Tien, MCELLIGOTT, David L, IRVIN, Thomas Combs, PUCA, Loredana, RAVI, Kannan Karukurichi, WELCH, Michael Brian, LONG, Katelyn Frances, ARONOW, Sean Douglas, KNIGHT, Jennifer Lynn, BOYLES, Nicholas A, KUMAR, Manoj, KLIPPEL-GIESE, Anke, MAYNE, Christopher Glenn, DAHLGREN, Markus K, KESICKI, Edward A
• Format: Patent
• Language: Spanish
• Published: 16.02.2023
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

La descripción se refiere a los compuestos de la Fórmula (I) como inhibidores alostéricos de cromenona del fosfoinosítido 3-quinasa (PI3K) útiles en el tratamiento de enfermedades o trastornos asociados con la modulación del PI3K, Fórmula (I): (I), o un profármaco, solvato, enantiómero, estereoisómero, tautómero o sal farmacéuticamente aceptable de este, en donde R1, R2, R3, R4, R5, R6, R7, R8, R9, W, X, Y, s, y el Anillo A son como se describen en la presente descripción. The disclosure relates to compounds of Formula (I) as allosteric chromenone inhibitors of phosphoinositide 3-kinase (PI3K) useful in the treatment of diseases or disorders associated with PI3K modulation, Formula (I):or a prodrug, solvate, enantiomer, stereoisomer, tautomer, or pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, W, X, Y, s, and Ring A are as described herein.