Moduladores del regulador de la conductancia transmembrana de la fibrosis quística

• Main Authors: KHATUYA, Haripada, JOSHI, Pramod Virupax, MCCARTNEY, Jason, CLEVELAND, Thomas, ARUMUGAM, VIJAYALAKSMI, GROSS, Raymond Stanley, SILINA, Alina, MARELIUS, Gulin Erdogan, PIERRE, Fabrice Jean Denis, KRENITSKY, Paul John, HADIDA-RUAH, SARA SABINA, GROOTENHUIS, Peter Diederik Jan, BEAR, BRIAN RICHARD, COON, Timothy Richard, CLEMENS, Jeremy J, ANDERSON, COREY, ZHOU, Jinglan, MILLER, Mark Thomas, LIN, Chun-Chieh, BINCH, Hayley Marie, FRIEMAN, Bryan A, NICHOLLS, Georgia McGaughey, TERMIN, Andreas P, UY, Johnny, MELILLO, Vito, CONROY, Erica
• Format: Patent
• Language: Spanish
• Published: 10.11.2017
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF; TRAPPING

La presente invención caracteriza un compuesto de la fórmula I, una de sus sales farmacéuticamente aceptables, donde R1, R2, R3, W, X, Y, Z, n, o, p y q se definen en la presente, para el tratamiento de enfermedades mediadas por CFTR, como fibrosis quística.La presente invención también caracteriza composiciones farmacéuticas, método de tratamiento y sus kits. The present invention features a compound of formula I:or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.