Derivados de imidazol pentacíclicos fusionados

• Main Authors: SELBY, Matthew Duncan, ZHU, Zhaoning, KEYAERTS, Jean, SHAW, Michael Alan, SWINNEN, Dominique Louis Léon, QUINCEY, Joanna Rachel, HUTCHINGS, Martin Clive, DELIGNY, Michael, EVRARD, Yves, JOHNSON, James Andrew, FORICHER, Yann, DE HARO GARCIA, Teresa, SCHIO, Laurent, BROOKINGS, Daniel Christopher, MAC COSS, Malcolm, CALMIANO, Mark Daniel, JADOT, Sophie, XUAN, Mengyang, HEER, Jag Paul, FILOCHEROMME, BRUNO
• Format: Patent
• Language: Spanish
• Published: 29.09.2017
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Una serie de derivados de imidazol pentacíclicos fusionados, que son potentes moduladores de la actividad de TNFα humano, son en consecuencia beneficiosos en el tratamiento y/o prevención de diferentes enfermedades humanas, que incluyen trastornos autoinmunológicos e inflamatorios; trastornos neurológicos y neurodegenerativos; trastornos de dolor y nociceptivos; trastornos cardiovasculares; trastornos metabólicos; trastornos oculares; y trastornos oncológicos. En particular, la presente invención se relaciona con derivados de 6,7- dihidro-7,14-metanobencimidazo[1,2-b][2,5]benzodiazocin-5(14H)-ona y análogos de los mismos. A series of fused pentacyclic imidazole derivatives, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders. In particular, the present invention is concerned with 6, 7-dihydro-7, 14-methanobenzimidazo[1, 2-b][2,5]benzodiazocin-5(14H)-one derivatives and analogs thereof.