Pulmonary malarial vaccine

Particulate compositions for delivery, preferably pulmonary, which provide sustained release of antigens such as malarial antigens, preferably DNA and/or peptide and/or protein antigens, have been developed. In the preferred embodiment, aggregate nanoparticles are in the aerodynamic range of 1-5 mic...

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Bibliographic Details
Main Author EDWARDS DAVID A.,SUNG JEAN,PULLIAM BRIAN,WEHRENBERG-KLEE ERIC,SCHWARTZ EVAN,DREYFUSS PHILIP,KULKARNI SANDEEP,LIEBERMAN EREZ
Format Patent
LanguageEnglish
Published 11.07.2007
Subjects
CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES
DISINFECTION, STERILISATION, OR DEODORISATION OF AIR
HUMAN NECESSITIES
HYGIENE
MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES
MEDICAL OR VETERINARY SCIENCE
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Particulate compositions for delivery, preferably pulmonary, which provide sustained release of antigens such as malarial antigens, preferably DNA and/or peptide and/or protein antigens, have been developed. In the preferred embodiment, aggregate nanoparticles are in the aerodynamic range of 1-5 microns diameter and fly deep into the lungs. As the aggregate particles degrade in the body, MSP-1 and AMA-1 proteins are released into the blood stimulating a humoural immune response. The individual particles in the range of 0.1 micron are preferentially phagocytosed by APCs which express the proteins encoded by AMA-1 and MSP-1 plasmid DNA thereby initiating the cellular immune response that is necessary for a complete immunity.
Bibliography:Application Number: CN200580022705