Diastereoselective reductive amination process

This invention describes a reductive amination process whereby perfluorinated ketones or ketals are combined with a-aminoesters under basic conditions to form metal carboxylates. Diastereoselective reductions of the metal carboxylates enable access to two diastereomers, depending on the reducing con...

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Bibliographic Details
Main Author CHEN CHENG Y.,DEVINE PAUL N.,FOSTER BRUCE S.,HUGHES GREG,O'SHEA PAUL
Format Patent
LanguageEnglish
Published 04.07.2007
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:This invention describes a reductive amination process whereby perfluorinated ketones or ketals are combined with a-aminoesters under basic conditions to form metal carboxylates. Diastereoselective reductions of the metal carboxylates enable access to two diastereomers, depending on the reducing conditions.
Bibliography:Application Number: CN200580026200