Improved cytokine design

• Main Author: TUR VICENTE R.,VAN DER SLOOT ALBERT MARTINUS,MULLALLY MARGARET M.,COOL ROBERT H.,SZEGEZDI EVA E.,SAMALI AFSHIN,FERNANDEZ-BALLESTER GREGORIO,SERRANO LUIS,QUAX WILHELMUS J
• Format: Patent
• Language: English
• Published: 07.03.2007
• Subjects: CHEMISTRY; INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS

The present invention relates to novel methods for the design of proteins, in particular, cytokines. These methods allow the stabilisation of such cytokines, as well as modification of their selectivity/specificity for their cognate receptors. The invention also relates to various modified proteins...