Improved cytokine design

The present invention relates to novel methods for the design of proteins, in particular, cytokines. These methods allow the stabilisation of such cytokines, as well as modification of their selectivity/specificity for their cognate receptors. The invention also relates to various modified proteins...

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Bibliographic Details
Main Author TUR VICENTE R.,VAN DER SLOOT ALBERT MARTINUS,MULLALLY MARGARET M.,COOL ROBERT H.,SZEGEZDI EVA E.,SAMALI AFSHIN,FERNANDEZ-BALLESTER GREGORIO,SERRANO LUIS,QUAX WILHELMUS J
Format Patent
LanguageEnglish
Published 07.03.2007
Subjects
CHEMISTRY
INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
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Summary:The present invention relates to novel methods for the design of proteins, in particular, cytokines. These methods allow the stabilisation of such cytokines, as well as modification of their selectivity/specificity for their cognate receptors. The invention also relates to various modified proteins that have been designed by the methods of the invention.
Bibliography:Application Number: CN200480040734