4-amino-quinoline ouinolizidinyl-and quinolizidinylalkyl-derivatives with antimalarial activity

The present invention relates to 4-amino-quinoline quinolizidinyl- and quinolizidinylalkyl-derivatives with antimalarial activity, in particular compounds of the general formula (I), in which R and n are as defined in the description,pharmaceutically acceptable salts thereof, complexes thereof with...

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Bibliographic Details
Main Author SPARATORE ANNA,TARAMELLI D.,BASILICO N.,PARAPINI S.,SPARATORE F.,BOIDO VITO,CANU BOIDO C
Format Patent
LanguageEnglish
Published 24.01.2007
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to 4-amino-quinoline quinolizidinyl- and quinolizidinylalkyl-derivatives with antimalarial activity, in particular compounds of the general formula (I), in which R and n are as defined in the description,pharmaceutically acceptable salts thereof, complexes thereof with gold, rhodium or ruthenium and pharmaceutical compositions containing them. The compounds of the invention are active also on chloroquine-resistant strains of Plasmodium falciparum.
Bibliography:Application Number: CN200480038152