Production of hop extracts having oestrogenic and antiproliferative bioactivity

The present invention relates to a method for the production of a hop extract which is enriched in 8-prenylnaringenin with respect to 6-prenylnaringenin, which method comprises the steps of subjecting a hop product to (1) an isomerisation reaction in the presence of water as a solvent and in the pre...

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Bibliographic Details
Main Authors DE KEUKELEIRE DENIS, HEYERICK ARNE, MAES FRANCIS
Format Patent
LanguageChinese
English
Published 29.09.2010
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to a method for the production of a hop extract which is enriched in 8-prenylnaringenin with respect to 6-prenylnaringenin, which method comprises the steps of subjecting a hop product to (1) an isomerisation reaction in the presence of water as a solvent and in the presence of an amount of a base and (2) to at least one extraction. In that way a hop extract may be extract is obtained which contains 6-prenylnaringenin and 8-prenyinaringening in a ratio (8-prenylnaringenin x 100%)/(8-prenylnaringenin + 6prenyInaringenin) of at least 50%. The extract preferably also contains xanthohumol, the weight ratio of xanthohumol to 8-prenylnaringenin being at least 10.
Bibliography:Application Number: CN200480037757