T-type calcium channel inhibitor

There is provided a T-type calcium channel blocker that is a compound of formula (1), a pharmaceutically acceptable salt thereof or a solvate thereof: wherein Ar 1 is phenyl group, pyridyl group, furyl group or 2,1,3-benzoxadiazol-4-yl group; nitrogen-containing hetero ring moiety is 1,4-dihydropyri...

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Bibliographic Details
Main Authors MASUDA YUKINORI, MATSUMOTO HIROO, FURUKAWA TAIJI, YAMASHITA TORU, YAMADA OSAMU
Format Patent
LanguageChinese
English
Published 16.06.2010
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:There is provided a T-type calcium channel blocker that is a compound of formula (1), a pharmaceutically acceptable salt thereof or a solvate thereof: wherein Ar 1 is phenyl group, pyridyl group, furyl group or 2,1,3-benzoxadiazol-4-yl group; nitrogen-containing hetero ring moiety is 1,4-dihydropyridine ring or pyridine ring; Z is a group of formula (2) or CO 2 R 2 ; R a and R b are independentlyof each other C 1-6 alkyl group, ANR 8 R 9 , CH 2 OANR 8 R 9 , or the like; in case where the nitrogen-containing hetero ring moiety is 1,4-dihydropyridine ring, R 1 is C 1-6 alkyl group, ANR 8 R 9 ,AN(CH 2 CH 2 ) 2 NR 8 , AN(CH 2 CH 2 ) 2 O, AOR 8 or benzyl group; R 3 is hydrogen atom, C 1-20 alkyl group, ANR 8 R 9 , a group of formula or or the like.
Bibliography:Application Number: CN200480034584