Tropane derivatives as CCR5 modulators

The present invention provides compounds of formula (I) wherein, X, Y, R , R and R are as defined hereinabove. The compounds of the present invention are modulators, especially antagonists, of the activity of chemokine CCR5 receptors. Modulators of the CCR5 receptor may be useful in the treatment of...

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Bibliographic Details
Main Author BASFORD PATRICIA A.,STEPHENSON PETER T.,TAYLOR STEFAN C. J.,WOOD ANTHONY
Format Patent
LanguageEnglish
Published 20.12.2006
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides compounds of formula (I) wherein, X, Y, R , R and R are as defined hereinabove. The compounds of the present invention are modulators, especially antagonists, of the activity of chemokine CCR5 receptors. Modulators of the CCR5 receptor may be useful in the treatment of various inflammatory diseases and conditions, and in the treatment of infection by HIV and genetically related retroviruses.
Bibliography:Application Number: CN200610094113