5-substituted quinazolinone derivatives

Compounds which are alpha-1A/B adrenoceptor antagonists and which are represented by Formula I: wherein Q is a monocyclic or bicyclic optionally-substituted heterocyclic ring as defined herein; Z is -C(-O)- or -S(-O)2-; R and R' are lower alkyl; R5 is halogen, cyano, hydroxy, -R6, or -OR6; and...

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Main Author CHIN ELBERT,COURNOYER RICHARD L.,KEITZ PAUL F.,LEE EUN K.,LOPEZ-TAPIA FRANCISCO J.,MELVILLE CHRIS R.,PADILLA FERNANDO,WEINHARDT KLAUS K
Format Patent
LanguageEnglish
Published 11.10.2006
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Compounds which are alpha-1A/B adrenoceptor antagonists and which are represented by Formula I: wherein Q is a monocyclic or bicyclic optionally-substituted heterocyclic ring as defined herein; Z is -C(-O)- or -S(-O)2-; R and R' are lower alkyl; R5 is halogen, cyano, hydroxy, -R6, or -OR6; and R6 is alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, heterocyclo, or substituted heterocyclo; and pharmaceutically-acceptable salts, hydrates, prodrugs, and isomers thereof.
Bibliography:Application Number: CN200480025046