Fluorene derivative

This invention relates to a novel fluorene derivative having a characteristic structure in which guanidino group or the like functional group is linked to the fluorene structure via carbonyl group, or a salt thereof. The compound of the invention has an advantage in that it has high affinity for ser...

Full description

Saved in:
Bibliographic Details
Main Author YAMADA HIROYOSHI,ITAHANA HIROTSUNE,MORITOMO AYAKO,MATSUZAWA TAKAHO,HARADA KOICHIRO,FUJIYASU JIRO,KOGA YUJI,OKU MAKOTO,OKAZAKI TOSHIO,AKUZAWA SHINOBU,WATANABE TOSHIHIRO
Format Patent
LanguageEnglish
Published 04.10.2006
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online AccessGet full text

Cover

More Information
Summary:This invention relates to a novel fluorene derivative having a characteristic structure in which guanidino group or the like functional group is linked to the fluorene structure via carbonyl group, or a salt thereof. The compound of the invention has an advantage in that it has high affinity for serotonin receptor subtypes, particularly for 5-HT 2B receptor and 5-HT 7 receptor, and shows excellent pharmacological effects in comparison with the conventional compounds which have only one of the antagonistic activities of 5-HT 2B receptor and 5-HT 7 receptor, this is useful as a prophylactic antimigraine agent having high safety and excellent effect.
Bibliography:Application Number: CN200580000874