Thioamide analog compound synthesis method

The invention discloses a synthesis of an addition reaction which uses accelerant to catalyze alkali and hydrogen sulfide in order to synthesize relevant thioamide compounds by high yield. The concrete things are thioacetamide, propanethioamide, thioisonicotinamide, thiobenzamide, 2-cyanothioacetami...

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Bibliographic Details
Main Author KAIQIN ZHU
Format Patent
LanguageEnglish
Published 26.07.2006
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention discloses a synthesis of an addition reaction which uses accelerant to catalyze alkali and hydrogen sulfide in order to synthesize relevant thioamide compounds by high yield. The concrete things are thioacetamide, propanethioamide, thioisonicotinamide, thiobenzamide, 2-cyanothioacetamide, 4-chlorphenylthioacetamide, 4-methylthiobenzamide. The process of this invention is: dissolving nitrile in a suitable organic solvent, adding alkali solution and phase transfer catalyst, mixing adequately to homogeneous phase, then importing hydrogen sulfide until the reaction end and getting thioamide.
Bibliography:Application Number: CN2006149402