Preparation of 4-[4-(1-oxethylacyl-1-ethyl methyl benzene)]-4-ketobutyric acid

Production of 4-(4-(1-ethoxy-acid radical-1-methyl ethyl benzene))-4-ketobutyric acid is characterized by azeotropic water dividing, by alpha , alpha -dimethyl phenylacetic acid: alcohol: methylbenzene=1 mol: 2.5-3 mol: 250-300ml., at methylbenzene-4-sulfonic acid catalysis, generating alpha , alpha...

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Bibliographic Details
Main Authors QIHUA WU, MANZHOU ZHU, ZHENGUO ZHOU, XIANGMING MENG, QINGXIANG GUO, HUABIN HONG, JIYUAN CAI
Format Patent
LanguageEnglish
Published 12.10.2005
Edition7
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:Production of 4-(4-(1-ethoxy-acid radical-1-methyl ethyl benzene))-4-ketobutyric acid is characterized by azeotropic water dividing, by alpha , alpha -dimethyl phenylacetic acid: alcohol: methylbenzene=1 mol: 2.5-3 mol: 250-300ml., at methylbenzene-4-sulfonic acid catalysis, generating alpha , alpha -dimethyl ethyl phenylacetate, acid radical reacting at -20--10deg.C by alpha , alpha -dimethyl ethyl phenylacetate: succinic anhydride: dichloromethane=1mol: 1-1.2mol: 350-450ml., generating mixed acid, slowly cooling to -5--2.5deg.C, and crystallizing. Its advantages include simple process, low cost, high productivity and less by-product.
Bibliography:Application Number: CN2005137717