Use of carbon-2-modified-19-nor-vitamin D analogs to induce the formation of new bone

It has been discovered that the 2-carbon-modified derivatives of 1α,25-dihydroxyvitamin D3 specifically stimulate osteoblasts to form new bone. The ability of the 2-carbon-modified vitamin D analogs to stimulate new bone formation suggest that these compounds can be used where synthesis of new bone...

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Bibliographic Details
Main Authors DELUCA HECTOR F, PIKE J. WESLEY, SHEVDE NIRUPAMA K
Format Patent
LanguageEnglish
Published 17.08.2005
Edition7
Subjects
APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
BANDAGES, DRESSINGS OR ABSORBENT PADS
DENTISTRY
DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS
FILTERS IMPLANTABLE INTO BLOOD VESSELS
FIRST-AID KITS
FOMENTATION
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROSTHESES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
TREATMENT OR PROTECTION OF EYES OR EARS
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Summary:It has been discovered that the 2-carbon-modified derivatives of 1α,25-dihydroxyvitamin D3 specifically stimulate osteoblasts to form new bone. The ability of the 2-carbon-modified vitamin D analogs to stimulate new bone formation suggest that these compounds can be used where synthesis of new bone is required. Thus, these compounds can be used either systemically or locally to stimulate the growth of bone transplants, to increase the rate of fracture healing and thereby reduce the time required for the healing of fractures, the stimulation of bone growth when required for replacement surgery, and also for the growth of bone to implants or other devices required to maintain the skeleton or teeth in the proper positions.
Bibliography:Application Number: CN20038011968