N-methyl (p-phenoxy, phenoxy) acetamide and its preparation method

The invention discloses a novel N-methyl (p-phenoxy,phenoxy) acetamide and its preparation method. The preparation process comprises the following steps: a. aminolysis reaction between methyl chloroacetate and Methylamine alcohol solution at low temperature, and separating to intermediate 2-chlorace...

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Bibliographic Details
Main Authors JIANWEI TAO, DONGYUAN JIN, JIANSHENG GU
Format Patent
LanguageEnglish
Published 06.07.2005
Edition7
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention discloses a novel N-methyl (p-phenoxy,phenoxy) acetamide and its preparation method. The preparation process comprises the following steps: a. aminolysis reaction between methyl chloroacetate and Methylamine alcohol solution at low temperature, and separating to intermediate 2-chloracetyl methylamine; b. heating phenoxy phenol and anhydrous potassium carbonate in organic solvent N,N-dimethylformamide(DMF) to produce phenolate; c. reaction between said phenolate and said 2-chloracetyl methylamine in DMF to produce product N-methyl (p-phenoxy,phenoxy) acetamide in yield between 85% and 88% and purity over 99%.
Bibliography:Application Number: CN2004184390