N-methyl (p-phenoxy, phenoxy) acetamide and its preparation method
The invention discloses a novel N-methyl (p-phenoxy,phenoxy) acetamide and its preparation method. The preparation process comprises the following steps: a. aminolysis reaction between methyl chloroacetate and Methylamine alcohol solution at low temperature, and separating to intermediate 2-chlorace...
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Main Authors | , , |
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Format | Patent |
Language | English |
Published |
06.07.2005
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Edition | 7 |
Subjects | |
Online Access | Get full text |
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Summary: | The invention discloses a novel N-methyl (p-phenoxy,phenoxy) acetamide and its preparation method. The preparation process comprises the following steps: a. aminolysis reaction between methyl chloroacetate and Methylamine alcohol solution at low temperature, and separating to intermediate 2-chloracetyl methylamine; b. heating phenoxy phenol and anhydrous potassium carbonate in organic solvent N,N-dimethylformamide(DMF) to produce phenolate; c. reaction between said phenolate and said 2-chloracetyl methylamine in DMF to produce product N-methyl (p-phenoxy,phenoxy) acetamide in yield between 85% and 88% and purity over 99%. |
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Bibliography: | Application Number: CN2004184390 |