Regulation of immune responses by manipulation of intermediary metabolite levels

• Main Author: MARGALIT MAYA,IIAN YARON,ENGELHARDT DEAN L.,RABBANI ELAZAR
• Format: Patent
• Language: Chinese; English
• Published: 03.11.2004
• Edition: 7
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

本发明涉及调节罹患疾病例如癌症、感染(例如病毒性感染、细菌性感染)或免疫功能障碍特别是自身免疫疾病(例如糖尿病、节段性回肠炎、类风湿性关节炎、动脉硬化和溃疡性结肠炎)的哺乳动物受试者(例如人)的免疫应答的新方法。更具体而言，本发明涉及产生升高水平的中间代谢物，例如脂类或缀合生物分子例如糖脂、脂蛋白以及除抗体、细胞因子或激素之外的糖蛋白。通过在患病受试者中引入中间代谢物、或通过给予后可导致其水平升高的试剂进行治疗。治疗方法可以是体内或离体。 The present invention provides novel processes for regulating immune responses in mammalian subjects, e.g., humans, afflicted with diseases such as cancers, infections, e.g., viral infections, bacterial infections, or immune dysfunctions, especially auto-immune disorders, e.g., diabetes, Crohn's disease, rheumatoid arthritis, arteriosclerosis and ulcerative colitis. More particularly, this invention relates to generating elevated levels of an intermediary metabolite, e.g., lipids or conjugated biomolecules, e.g., glycolipids, lipoproteins and glycoproteins other than antibodies, cytokines or hormones. Treatment can be carried by introduction of the intermediary metabolite into the afflicted subject or by a reagent that when administered leads to elevated levels. The treatment regimen can be in vivo or ex vivo.